Multiple-dose pharmacokinetics of telithromycin in peripheral soft tissues
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers.
By use of microdialysis we assessed the concentrations of telithromycin in muscle and adipose tissue to test its ability to penetrate soft tissues. The ratios of the area under the concentration-versus-time curve from 0 to 24 h to the MIC indicated that free concentrations of telithromycin in tissue and plasma might be effective against Streptococcus pyogenes but not against staphylococci and h...
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The antimicrobial spectrum of clarithromycin renders this antibiotic a frequently used option in the treatment of skin and soft-tissue infections. In most cases, these infections are caused by extracellularly proliferating microorganisms. Thus, clarithromycin concentrations achieved in the interstitial space are considered particularly important for clinical efficacy. In the present study, clar...
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Telithromycin (HMR 3647) is a novel ketolide antimicrobial with good activity against both common and atypical respiratory pathogens, including many resistant strains. This randomized, three-period crossover study determined the dose proportionality of telithromycin pharmacokinetics after single and multiple dosing in healthy subjects. In each treatment period, subjects received a single oral d...
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ژورنال
عنوان ژورنال: International Journal of Antimicrobial Agents
سال: 2009
ISSN: 0924-8579
DOI: 10.1016/j.ijantimicag.2009.01.016